Pregelatinized starch (USP) is a modified starch that's been processed to make it readily dispersible in cold water. It's a common ingredient used in various pharmaceutical applications due to its functional properties. Here's a closer look at pregelatinized starch (USP):
Properties:
Appearance: Fine white powder.
Solubility: Easily disperses in cold water to form a viscous suspension or paste. This is in contrast to unmodified starch, which requires heating to gelatinize (activate) in water.
Stability: Relatively stable with a long shelf life when stored properly.
Functions in Pharmaceuticals:
Excipient: Pregelatinized starch is a versatile excipient, meaning it's an inactive ingredient added to medications to aid in their formulation, manufacturing, and functionality. Here are some specific functions it serves:
Binder: Helps bind together tablet or capsule ingredients to create a solid dosage form.
Disintegrant: Promotes the breakdown of tablets or capsules into smaller particles after they are swallowed, facilitating faster drug release and absorption.
Glidant: Improves the flowability of powdered ingredients during manufacturing.
Thickener: Can be used as a thickener in some liquid formulations.
